Geometric Catalysis of Membrane Fission Driven by Flexible Dynamin Rings
نویسندگان
چکیده
منابع مشابه
Dynamin - Mediated Membrane Fission
The eucaryotic cell is organized in several compartments named organelles. These organelles and the cell itself are delimited by lipid membranes. The ssion of these membranes is required for the vesicular tra c between organelles. Endocytosis is the mechanism of vesicular tra c from the plasma membrane towards other organelles inside the cell. Dynamin is a guanosine triphosphatase implicated in...
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The GTPase dynamin has captivated researchers for over two decades, even managing to establish its own research field. Dynamin's allure is partly due to its unusual biochemical properties as well as its essential role in multiple cellular processes, which include the regulation of clathrin-mediated endocytosis and of actin cytoskeleton. On the basis of the classic model, dynamin oligomerization...
متن کاملStructural inhibition of dynamin-mediated membrane fission by endophilin
Dynamin, which mediates membrane fission during endocytosis, binds endophilin and other members of the Bin-Amphiphysin-Rvs (BAR) protein family. How endophilin influences endocytic membrane fission is still unclear. Here, we show that dynamin-mediated membrane fission is potently inhibited in vitro when an excess of endophilin co-assembles with dynamin around membrane tubules. We further show b...
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1 Dynamin is a mechanochemical GTPase essential for membrane fission during clathrin 2 mediated endocytosis. Dynamin forms washer ring-shaped/helical complexes at the neck of 3 clathrin-coated pits and their structural changes coupled with GTP hydrolysis drive membrane 4 fission. Dynamin and its binding protein amphiphysin cooperatively regulates membrane 5 remodeling during fission, but its pr...
متن کاملBAR Domain Scaffolds in Dynamin-Mediated Membrane Fission
Biological membranes undergo constant remodeling by membrane fission and fusion to change their shape and to exchange material between subcellular compartments. During clathrin-mediated endocytosis, the dynamic assembly and disassembly of protein scaffolds comprising members of the bin-amphiphysin-rvs (BAR) domain protein superfamily constrain the membrane into distinct shapes as the pathway pr...
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ژورنال
عنوان ژورنال: Science
سال: 2013
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1233920